產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號(hào) | 型號(hào) |
HZ-1157 | 5mg 25mg | 1009734-33-1 | EY-Y0164521 |
Cas No.1009734-33-1
別名
化學(xué)名 5-(tert-butoxy)quinazoline-2,4-diamine
分子式 C12H16N4O
分子量 232.28
溶解度 ≥ 11.6mg/mL in DMSO
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 μmol/L [1].
The NS3 protease of HCV is a prime target for the development of anti-HCV agents because it cleaves the viral polyprotein and liberates NS3, NS4A, NS4B, NS5A, and NS5B, allowing them to function normally in viral RNA replication, and it deactivates many host proteins involved in innate immunity to foster a favorable cellular environment for HCV replication. The NS3 protease is most active when complexed with its cofactor NS4A [1].
In vitro: Huh7.5.1 cell line stably transfected with HCV NS3/4A protease reporter was established to investigate the anti-HCV mechanism of HZ-1157 (0.001~1 μmol/L). The results showed that HZ-1157 exhibited inhibitory effect on the HCV NS3/4A protease with IC50 value of 1.0 μmol/L. HZ-1157 was further tested against an infectious HCV virus (J399EM) which can infect and replicate in Huh7.5.1 cells in vitro. The results showed that HZ-1157 effectively inhibited J399EM virus replication in Huh7.5.1 cells with IC50 value of 0.82 μmol/L [1].
Reference:
[1]. Yu Y, Jing J, Tong X, et al. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease[J]. Acta Pharmacologica Sinica, 2014, 35(8): 1074.
關(guān)鍵字： 1009734-33-1;C12H16N4O;HZ-1157;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來(lái)，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運(yùn)用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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