Host:Rabbit
Target Protein:MEKK3
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:4215
Swiss Prot:Q99759
Source:KLH conjugated synthetic peptide derived from human MEKK3:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:50-200)
IHC-F(1:50-200)
Flow-Cyt(1:50)
ICC(1:50)
Cross Reactive Species:Human
Mouse
Rat
本產品僅供科研使用。不能用于人和動物治療等其它臨床診斷使用！
關鍵字： MEKK3;MEKK3;MAPKKK3; MEK kinase 3;MAP3K3;
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