英文別名

BMP2; BMP-2; BMP2A; BMP-2A; bone morphogenetic protein 2 (osteogenic); bone morphogenetic protein 2; Bone morphogenetic protein 2A; bone morphogenetic protein-2; Osteogenin

背景

Bone morphogenetic protein 2 (BMP-2) belongs to the TGF-β superfamily of proteins (1).BMP-2 has been shown to interact with BMPR1A. BMP-2 like other bone morphogenetic proteins (2) plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.BMP-2 and BMP-7 are osteo-inductive BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types (3).