Mouse  Anti-C-erbB-2/HER2 Monoclonal Antibody
DATASHEET

Host:Mouse

Target Protein:C-erbB-2/HER2

IR:Immunogen Range:full length

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:2064

Swiss Prot:P04626

Source:Recombinant human HER2 protein:full length 

Purification:affinity purified by Protein G

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-1000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)

Cross Reactive Species:Human
Mouse
Rat

本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！