Rabbit Anti-GPX4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:GPX4
IR:Immunogen Range:101-197/197
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2879
Swiss Prot:P36969
Source:KLH conjugated synthetic peptide derived from human Glutathione Peroxidase 4:101-197/197
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： GPX4;Glutathione peroxida;GPX4;MCSP;mitochondrial PHGPx;Phospholipid ;snGPx;GPX4_HUMAN;
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