Rabbit Anti-Syncytin 1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Syncytin 1
IR:Immunogen Range:451-538/538
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:30816
Swiss Prot:Q9UQF0
Source:KLH conjugated synthetic peptide derived from human Syncytin 1:451-538/538
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
本品僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： Syncytin 1;HERV-W_7q21.2 provir;Endogenous retroviru;env;nv-W;Envelope polyprotein;Enverin;ENW1_HUMAN;
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