Rabbit Anti-phospho-CDK5 (Tyr15) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-CDK5 (Tyr15)
IR:Immunogen Range:GT(p-Y)GT
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1020
Swiss Prot:Q00535
Source:KLH conjugated synthesised phosphopeptide derived from human CDK5 around the phosphorylation site of Tyr15:GT(p-Y)GT
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:CDK5 (Cyclin Dependent Kinase 5) is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Mouse
Rat
Chicken
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： phospho-CDK5 (Tyr15);Cdk5 (phospho Y15);p-Cdk5(Y15);Cdk 5;Cell division protei;Crk6;PSSALRE;CDK5_HUMAN;
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