Rabbit Anti-phospho-FAK (Tyr577) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-FAK (Tyr577)
IR:Immunogen Range:TY(p-Y)KA
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5747
Swiss Prot:Q05397
Source:KLH conjugated Synthesised phosphopeptide derived from human FAK around the phosphorylation site of Tyr577:TY(p-Y)KA
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： phospho-FAK (Tyr577);FAK (phospho Y577);p-FAK (phospho Y577);FADK;FAK 1;FAK1;FRNK;PPP1R71;
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