Rabbit Anti-SARM1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:SARM1
IR:Immunogen Range:321-420/724
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23098
Swiss Prot:Q6SZW1
Source:KLH conjugated synthetic peptide derived from human SARM1:321-420/724
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關(guān)鍵字： SARM1;FLJ36296;KIAA0524;MyD88-5; SAM and ARM-contain;SAMD2;SARM 1;SARM1_HUMAN;
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