Rabbit  Anti-STAT3 Monoclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:STAT3

IR:Immunogen Range:

Clonality:Monoclonal

Isotype:IgG

Entrez Gene:6774

Swiss Prot:P40763

Source:Recombinant human Stat3 protein (1-100aa): 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-1000)
IHC-P(1:100-500)
IHC-F(1:50-200)
Flow-Cyt(2ug/Test)
ICC(1:50-200)
IF(1:50-200)

Cross Reactive Species:Human
Mouse
Rat
Zebrafish

僅供科研使用。不能用于人和動物治療等其它臨床診斷用！