Product Name：ProTx II
CAS No.：484598-36-9
Synonyms：選擇性阻滯劑多肽ProTx II
Catalog No.：218P444
Brand：HongTide（上海鴻肽生物）
Description：ProTx II一種Nav1.7 鈉通道的選擇性阻滯劑多肽，序列中含有30個(gè)氨基酸，并且包含三對(duì)二硫鍵，IC50 值為 0.3 nM，對(duì) Nav1. 7的選擇性是其他鈉通道亞型的至少 100 倍。ProTx-II 通過降低通道電導(dǎo)和將激活的電壓轉(zhuǎn)移到更多的正電位來抑制鈉離子通道，并阻止傷害感受器中動(dòng)作電位的傳播。
ProTx II is a selective blocking peptide of Nav1.7 sodium channel, which contains 30 amino acids in its sequence and three pairs of disulfide bonds. Its IC50 value is 0.3 nM, which affects Nav1 The selectivity of 7 is at least 100 times that of other sodium channel subtypes. ProTx-II suppresses sodium ion channels and prevents the propagation of action potentials in nociceptors by reducing channel conductivity and transferring activated voltage to more positive potentials.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YCQKWMWTCDSERKCCEGMVCRLWCKKKLW(Disulfide bridge：Cys2-Cys16;Cys9-Cys21;Cys15-Cys25) |
Sequence(3-letter code) | H-Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp-OH(Disulfide bridge：Cys2-Cys16;Cys9-Cys21;Cys15-Cys25) |
Peptide Structure | 
|
Molecular Formula | C168H250N46O41S8 |
Molecular Weight | 3826.59 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
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郵箱：sales1@hongtide.com
關(guān)鍵字： 484598-36-9;ProTx II ;選擇性阻滯劑多肽ProTx II;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。