等級

certified reference material
pharmaceutical secondary standard

一般描述

Isotretinoin is a vitamin A derivative, obtained from the isomerization of retinoic acid in the body. It is therapeutically used to treat severe recalcitrant nodular acne. It is also reported to exhibit anti-inflammatory and anti-tumor activities.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Isotretinoin may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

13- 順 -維甲酸 (RA) 具有抗炎和抗腫瘤操作。RA 的操作是通過 RAR-β 介導的和 RAR-α受體。RA 可減弱細胞因子刺激的小鼠系膜細胞 iNOS 的表達和活性。它誘導線粒體膜通透性轉換，觀察為腫脹和膜電位降低，并通過細胞凋亡途徑刺激細胞色素 c 的釋放牽連機制。這些活動被 EGTA 和環(huán)孢霉素 A 逆轉。RA 也部分通過增加轉錄增加 MMP-1 蛋白表達。

分析說明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.