別名

MCI-186 - CAS 89-25-8 - Calbiochem,3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone

一般描述

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore. A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore.

生化/生理作用

Cell permeable: no Primary Target
A free radical scavenger and antioxidant Product does not compete with ATP. Reversible: no Target IC50: 15 μM inhibiting iron-dependent peroxidation in rat brain homogenates

重懸

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說(shuō)明

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.