中文名：CB-103
英文名：CB-103
純度：Moligand?，≥98%
貨號(hào)：C414475
Cas號(hào)：218457-67-1
存儲(chǔ)溫度：-20°C儲(chǔ)存
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Information
CB-103 CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.
Targets
Notch
In vitro
CB-103 inhibits growth of Notch-addicted human T cell acute lymphoblastic leukemia cell lines through modulation of the Notch transcription complex.
In vivo
CB-103 function in vivo recapitulates genetic notch loss-of-function phenotypes without causing gut toxicity. CB-103 blocks tumor growth of GSI-resistant cancers.
Cell Research(from reference)
Cell lines：marrow mesenchymal stroma cells (MSCs), RPMI-8402 cells?
Concentrations：10 nM to 25 μM, 1 μM?
Incubation Time：3 days, 1 h, 4 h, 24 h?
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關(guān)鍵字： CCG-233915 ; EX-A4302 ; 6-(4-(tert-Butyl)phenoxy)pyridin-3-amine ; 6-(4-(1,1-Dimethylethyl)phenoxy)-3-pyridinamine [WHO-DD]
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