中文名：iHAP1

英文名：iHAP1

純度：10mM in DMSO

貨號：I580566

Cas號：105925-39-1

存儲溫度：-80℃儲存

運輸條件：特低溫運輸

產(chǎn)品介紹：

Information

iHAP1 iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells.

Targets

PP2A

In vitro

Phenothiazine analog iHAP1 activates PP2A-B56ε and potently kills malignant cells. iHAP1 does not inhibit dopamine signaling or cause prohibitive neurologic toxicity. The PP2A complex activated by iHAP1 dephosphorylates the MYBL2 transcription factor on Ser241, causing irreversible arrest of leukemia and other cancer cells in prometaphase.

In vivo

In preclinical testing against T-ALL xenografts, iHAP1 emerges as a much more promising compound than PPZ, showing improved antitumor activity and lack of toxicity.

Cell Research(from reference)

Cell lines：HEK293T cells?

Concentrations：0.5 μM?

Incubation Time：3 h?

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