中文名：Osilodrostat (LCI699)
英文名：Osilodrostat (LCI699)
純度：Moligand?，≥99%
貨號：O413758
Cas號：928134-65-0
存儲溫度：-20°C儲存
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Information
Osilodrostat (LCI699) LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B) , an enzyme catalyzing the final step of cortisol synthesis.
Targets
11β-hydroxylase 2.5 nM
In vitro
LCI699 also inhibits aldosterone synthase (CYP11B2) other than CYP11B1.
In vivo
LCI699 is a potent inhibitor of 11β-hydroxylase (CYP11B1), the enzyme that catalyzes the final step of cortisol synthesis, and has a half-life of ～4 hours. It decreases blood pressure (BP) in patients with essential hypertension and primary aldosteronism. Treatment with LCI699 is well tolerated, it is demonstrated efficacy with a satisfactory safety and tolerability profile in the proof-of-concept study in Cushing\'s disease. The administration of LCI699, up to 1.0 mg BID, effectively and safely inhibits aldosterone synthase in patients with primary aldosteronism.
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關(guān)鍵字： 奧西洛司他 (LCI699);(R)-4-(6,7-Dihydro-5H-pyrrolo(1,2-c)imidazol-5-yl)-3-fluorobenzonitrile ; GTPL8310 ; 5YL4IQ1078
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