中文名：泊馬度胺 4'-PEG3-酸
英文名：Pomalidomide 4'-PEG3-acid
純度：≥95%(HPLC)，PROTAC
貨號：P288042
Cas號：2138440-82-9
存儲溫度：-20°C儲存
運輸條件：超低溫運輸
產(chǎn)品介紹：
Product Application:
Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
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關(guān)鍵字： 3-[2-[2-[2-[[2-(2,6-二氧代-3-哌啶基)-2,3-二氫-1,3-二氧代-1H-異吲哚-4-基]氨基]乙氧基]乙氧基]乙氧基]丙酸;Pomalidomide - linker 2 ; 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid ; Crosslinker?E3 Ligase ligand conjugate
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