中文名：TRx0237 (LMTX) mesylate
英文名：TRx0237 (LMTX) mesylate
純度：≥98%
貨號：T413826
Cas號：1236208-20-0
存儲溫度：-20°C儲存
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Information
TRx0237 (LMTX) mesylate TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
Targets
tau protein aggregation
In vitro
TRx 0237 (LMTX?) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer\'s disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer\'s Disease brain tissues at the concentration at 0.16 μM.
In vivo
TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66.
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關(guān)鍵字： TRx0237 (LMTX) 甲磺酸鹽;TRx0237 mesylate;Methylene blue leuco base mesylate ; LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE) ; Leucomethylene blue Mesylate
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