中文名：2-嗎啉基-4H-嘧啶并[2,1-a]異喹啉-4-酮

英文名：2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

純度：≥98%(HPLC)

貨號：M157859

Cas號：168425-64-7

存儲溫度：避光,-20°C儲存

運輸條件：超低溫運輸

產(chǎn)品介紹：

Product Introduction

A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.?

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