中文名：GTP 14564,III類受體酪氨酸激酶（RTK）抑制劑
英文名：GTP 14564
純度：Moligand?，≥99%
貨號：G287870
Cas號：34823-86-4
存儲溫度：避光,-20°C儲存
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Product description：
A cell-permeable, reversible, ATP-competitive, and tricyclic, benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 300 nM for c-fms, c-kit, wt-FLT3, and internal tandem duplication (ITD)-FLT3; 1 μM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, Akt, PKC, MEK, or ERK1/2 (IC50 >10 μM). Inhibits FLT-3 ligand-dependent growth of Ba/F3 cells expressing wild type FLT-3. Reported to be useful in differentiating signal transduction pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
A cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 0.3 μM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 μM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, AKT, PKC, MEK, or ERK1/2 (IC50 ≥ 10 μM). Has been used successfully to differentiate between the signalling pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
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關(guān)鍵字： 3-苯基-1H-苯并呋喃[3,2-c]吡唑;HSCI1_000176 ; BRD-K16664969-001-01-7 ; GTPL5982
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