中文名：洛莫司汀
英文名：Lomustine
英文別名：NSC79037, Gleostine, CeeNU, CCNU;N-?(2-?chloroethyl)?-?N'-?cyclohexyl-?N-?nitroso-urea
純度：10mM in DMSO
貨號(hào)：L409232
包裝：1ml
Cas號(hào)：13010-47-4
存儲(chǔ)溫度：-80℃儲(chǔ)存
產(chǎn)品介紹：
Information
Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging theDNAand stops cells from dividing.
In?vitro
Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 μM and 15 μM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-alkylguanine-DNA alkyltransferase. Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
In?vivo
Lomustine can cause delayed, cumulative dose-related, chronic hepatotoxicity that is irreversible and can be fatal. Lomustine could result in infrequent severe hematological toxicity in cats with spontaneously arising tumors, and the incidence of either grade III or IV neutropenia and thrombocytopenia is 4.1% and 1.0%, respectively. Lomustine trends toward a greater likelihood for progressive neutropenia and statistically significant higher response rates in cats with spontaneously arising tumors.
Cell?Data
cell?lines：A375 cells
Concentrations：133 μM
Incubation?Time：1 hour
Powder?Purity:≥98%
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關(guān)鍵字： NSC79037, Gleostine, CeeNU, CCNU;N-?(2-?chloroethyl)?-?N'-?cyclohexyl-?N-?nitroso-urea
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