中文名：特立氟胺

英文名：Teriflunomide

純度：≥99%

貨號：T124990

Cas號：163451-81-8

存儲溫度：2-8°C儲存

運輸條件：低溫運輸

產品介紹：

A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thoμght to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.

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