B7-H3 (4Ig)產(chǎn)品信息

英文名稱：CD276 antigen

中文名稱：CD276抗原

靶點(diǎn)別稱：4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309,PRO352,B7 homolog 3

物種：Human / Cynomolgus

屬性：Protein / Cell

標(biāo)記：Biotin-labeled / FITC Labeled / Unconjugated / PE Labeled

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 24 months in lyophilized state;

2. -70°C for 24 months under sterile conditions after reconstitution.

B7-H3 (4Ig)分子背景

B7同源物3（B7-H3）是免疫球蛋白超家族的成員，也被稱為CD276，它包含兩個(gè)Ig樣C2型（免疫球蛋白樣）結(jié)構(gòu)域和兩個(gè)Ig型V型（免疫蛋白樣）的結(jié)構(gòu)域。B7-H3可能參與調(diào)節(jié)T細(xì)胞介導(dǎo)的免疫反應(yīng)。B7-H3還通過抑制自然殺傷介導(dǎo)的細(xì)胞裂解在腫瘤細(xì)胞中發(fā)揮保護(hù)作用，并作為檢測(cè)神經(jīng)母細(xì)胞瘤細(xì)胞的標(biāo)志物。此外，B7-H3參與急性和慢性移植排斥反應(yīng)的發(fā)展以及粘膜表面淋巴細(xì)胞活性的調(diào)節(jié)。它還可以在整個(gè)懷孕期間為胎盤和胎兒提供合適的免疫環(huán)境方面發(fā)揮關(guān)鍵作用。

B7-H3 (4Ig)用戶評(píng)價(jià)