Annexin A5產(chǎn)品信息

物種：Human

標(biāo)簽：Tag Free / His Tag & Avi Tag / His Tag

屬性：Protein

標(biāo)記：Biotin-labeled / Unconjugated

分子別名（Synonym）

ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5

內(nèi)毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

無(wú)菌（Sterility）

The sterility testing was performed by membrane filtration method.

支原體（Mycoplasma）

Negative.

純度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Annexin A5分子背景

Annexin A5是一種磷脂結(jié)合蛋白，在鈣的存在下以高親和力和選擇性結(jié)合PS。PS主要位于面向細(xì)胞質(zhì)的膜小葉中。然而，最近的研究結(jié)果表明，每種細(xì)胞類型都有在其細(xì)胞表面暴露PS的分子機(jī)制。這種機(jī)制在細(xì)胞凋亡過(guò)程中被激活。一旦PS暴露在細(xì)胞表面，它就會(huì)表現(xiàn)出促凝和促炎活性。Annexin A5會(huì)與PS暴露的凋亡細(xì)胞結(jié)合，并能抑制垂死細(xì)胞的促凝和促炎活性。Annexin A5也被確定為凝血級(jí)聯(lián)中的一種抗凝蛋白，作為凝血酶原激活的抑制劑。Annexin A5抗體的存在與系統(tǒng)性紅斑狼瘡（SLE）、復(fù)發(fā)性自然流產(chǎn)和系統(tǒng)性硬化癥（SSc）有關(guān)。