中文名：Elimusertib (BAY-1895344)
英文名：Elimusertib (BAY-1895344)
純度：Moligand?，≥98%
貨號：E414498
Cas號：1876467-74-1
存儲溫度：-20°C儲存
運輸條件：超低溫運輸
產(chǎn)品介紹：
Information
Elimusertib (BAY-1895344) is a very potent and highly selectiveATR (ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.
Targets
ATR (Cell-free assay) 7 nM
In vitro
BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines.
In vivo
BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.
Cell Research(from reference)
Cell lines：HT-29 cells, M059J cells, 38 cancer cell lines?
Concentrations：3–300 nM?
Incubation Time：72 to 96 hours?
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關(guān)鍵字： GTPL10354 ; HY-101566 ; BAY-1895344 HCl ; 1,7-NAPHTHYRIDINE, 2-((3R)-3-METHYL-4-MORPHOLINYL)-4-(1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-3-YL)-
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