中文名：LFM-A13,BTK抑制劑
英文名：LFM-A13
純度：≥98%(HPLC)
貨號(hào)：L286934
Cas號(hào)：62004-35-7
存儲(chǔ)溫度：避光,-20°C儲(chǔ)存
運(yùn)輸條件：超低溫運(yùn)輸
產(chǎn)品介紹：
Product description：
A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton’s Tyrosine Kinase (BTK; IC50 = 17.2 μM for human BTK in vitro and IC50 = 2.5 μM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC50 = 10 μM and 61 μM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 μM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton′s tyrosine kinase (BTK; IC50 = 17.2 μM for human BTK in vitro and IC50 = 2.5 μM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC50 = 10 μM and 61 μM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 μM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
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關(guān)鍵字： 2-氰基-N-(2,5-二溴苯基)-3-羥基-2-丁烯酰胺;AKOS028108222 ; alpha-Cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide ; KBio3_001038
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