Human Her2 / ErbB2 Protein, His Tag (MALS verified)
分子別名（Synonym）
ERBB2,CD340,HER-2,neu,HER2,MLN19,NEU,NGL,TKR1
表達區(qū)間及表達系統(tǒng)（Source）
Human Her2, His Tag (HE2-H5225) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # P04626-1).
Predicted N-terminus: Thr 23
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 70.2 kDa. The protein migrates as 70-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 0.2 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
背景（Background）
人表皮生長因子受體2（HER2）也稱為ERBB2，HER-2，HER-2/neu，neu，NGL，TKR1和c-erb B2，是一種在乳腺癌中具有更高侵襲性的蛋白質(zhì)。它是ErbB蛋白家族的成員，更常被稱為表皮生長因子受體家族。HER2被認(rèn)為是一種孤兒受體，EGF家族的配體都不能激活它。大約30%的乳腺癌具有HER2基因的擴增或其蛋白產(chǎn)物的過表達。該受體在乳腺癌中的過度表達與疾病復(fù)發(fā)增加和預(yù)后不良有關(guān)。HER2似乎在發(fā)育，癌癥，神經(jīng)肌肉接頭的通訊以及細胞生長和分化的調(diào)節(jié)中發(fā)揮作用。
關(guān)鍵字： Her2;Her2蛋白;Her2重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。