Human CD163 Protein, His Tag

分子別名（Synonym）

CD163,M130

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7).

Predicted N-terminus: Ser 42

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 110.4 kDa. The protein migrates as 135-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CD163是血紅蛋白-觸珠蛋白復(fù)合物的清道夫受體。CD163也被證明可以標(biāo)記單核細(xì)胞/巨噬細(xì)胞譜系的細(xì)胞。受體的可溶性形式存在于血漿中，通常表示為sCD163。sCD163是由膜結(jié)合受體的胞外區(qū)脫落產(chǎn)生的。sCD163在多種炎癥性疾病中上調(diào)，包括肝硬化、2型糖尿病、巨噬細(xì)胞活化綜合征、戈謝病、敗血癥、HIV感染、類風(fēng)濕性關(guān)節(jié)炎和霍奇金淋巴瘤。