Monkeypox virus (Democratic Republic of the Congo) A30L Protein, His Tag (MALS verified)
分子別名（Synonym）
A30L (MPXV)
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Monkeypox virus (Democratic Republic of the Congo) A30L Protein, His Tag (A3L-M5244) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Leu 146 (Accession # EPI_ISL_19093812, GISAID).
Predicted N-terminus: His
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 16.0 kDa. The protein migrates as 25-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
猴痘是由猴痘病毒引起的一種罕見(jiàn)的人畜共患病，猴痘病毒已成為最嚴(yán)重的正痘病毒，由復(fù)雜的雙鏈DNA組成。猴痘的發(fā)病機(jī)制是病毒從呼吸道粘膜侵入人體，在淋巴細(xì)胞中繁殖，并進(jìn)入血液，產(chǎn)生短暫的性病毒血癥。病毒在細(xì)胞中繁殖后，細(xì)胞可以侵入血液并傳播到全身皮膚，引起病變。A30L是病毒進(jìn)入宿主細(xì)胞和細(xì)胞融合（合胞體形成）所需的包膜蛋白。
關(guān)鍵字： A30L (MPXV);A30L (MPXV)蛋白;猴痘病毒蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。