化合物 AUT1|T5183|TargetMol

價(jià)格	￥322	￥787	￥1180
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2026-04-02

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產(chǎn)品詳情

中文名稱(chēng):化合物 AUT1	英文名稱(chēng):AUT1
CAS:1311136-84-1	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Keep away from moisture Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 99.95%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T5183

Product Introduction

Bioactivity

名稱(chēng)	AUT1
描述	AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
細(xì)胞實(shí)驗(yàn)	The population patch-clamp mode of an automated voltage clamp recording with IonWorks Quattro was used. Briefly, the effects on these channels were tested using 384-well population patch-clamp plates. Seal resistance was measured for each well, and cells were perforated by incubation with 100 mg/ml amphotericin B. Cells were held at 270 mV and stepped to 215 mV for 100 milliseconds (partial channel activation), and after 100 milliseconds at 270 mV, a second pulse to 140 mV was applied for 50 milliseconds (full channel activation). In all of the experiments, this voltage protocol was applied to cells before and following a 3-minute incubation with AUT1. 1-Cyclohexyl-1-[(7,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-3-phenylurea (10 mM), which we had previously found to be a potent and full activator of human Kv3.1 and Kv3.2 channels, was included in all assays as a standard. An external buffer with the addition of dimethyl sulfoxide (DMSO) was also tested to provide a vehicle baseline. Recordings were performed in the following buffers: Dulbecco's phosphate-buffered saline (PBS) with MgCl2 and CaCl2 as an extracellular solution and 50 mM KCl, 100 mM K-gluconate, 3.2 mM MgCl2, and 5 mM HEPES, pH 7.3 adjusted with KOH, as an intracellular solution. An online correction of 115–20 mV was applied to correct for junction potentials. The current signal was sampled at 10 kHz [1].
體外活性	AUT1增強(qiáng)了人類(lèi)重組Kv3.1b和Kv3.2a通道介導(dǎo)的電流。對(duì)于Kv3.1b和Kv3.2a，AUT1的pEC50值分別為5.33（4.7 μM）和5.31（4.9 μM）[1]。使用穩(wěn)定表達(dá)大鼠Kv3.1通道的中國(guó)倉(cāng)鼠卵巢細(xì)胞，較低濃度的AUT1可將Kv3.1電流的激活電壓向負(fù)電位移動(dòng)，從典型神經(jīng)元靜息電位引起的去極化所誘發(fā)的電流增加[2]。
存儲(chǔ)條件	Keep away from moisture Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (14.65 mM), Sonication is recommended. DMSO : 250 mg/mL (732.36 mM), Sonication is recommended.
關(guān)鍵字	schizophrenia \| recombinant human Kv3 channels \| PotassiumChannel \| Potassium Channel \| Kv3.2a channels \| Kv3.2a \| Kv3.1b channels \| Kv3.1b \| KcsA \| Inhibitor \| inhibit \| human recombinant \| dysfunction \| corticolimbic circuits \| AUT-1 \| AUT1 \| AUT 1
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關(guān)鍵字： AUT1|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專(zhuān)業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶(hù)群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿(mǎn)足不同需求的化合物庫(kù)，以及多種類(lèi)型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類(lèi)多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿(mǎn)足客戶(hù)的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專(zhuān)業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

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