| 價格 | ¥592 | ¥1430 | ¥2390 |
| 包裝 | 1mg | 5mg | 10mg |
| 最小起訂量 | 1mg |
| 發(fā)貨地 | 上海 |
| 更新日期 | 2026-06-29 |
| 中文名稱:化合物 GSK199 | 英文名稱:GSK199 |
| CAS:1549811-53-1 | 品牌: TargetMol |
| 產地: 美國 | 保存條件: Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 純度規(guī)格: 99.44% | 產品類別: 抑制劑 |
| 貨號: T001|T8861 |
| 名稱 | GSK199 |
| 描述 | GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium). |
| 體內活性 | GSK199, in the murine collagen-induced arthritis model of rheumatoid arthritis. Mice were dosed daily from the time of collagen immunization with GSK199. Efficacy was assessed against a wide range of end-points, including clinical disease scores, joint histology and immunohistochemistry, serum and joint citrulline levels and quantification of synovial autoantibodies using a proteomic array containing joint peptides. Administration of GSK199 at 30 mg/kg led to significant effects on arthritis, assessed both by global clinical disease activity and by histological analyses of synovial inflammation, pannus formation and damage to cartilage and bone. In addition, significant decreases in complement C3 deposition in both synovium and cartilage were observed robustly with GSK199 at 10 mg/kg. Neither the total levels of citrulline measurable in joint and serum, nor levels of circulating collagen antibodies, were affected significantly by treatment with GSK199 at any dose level. In contrast, a subset of serum antibodies reactive against citrullinated and non-citrullinated joint peptides were reduced with GSK199 treatment. |
| 存儲條件 | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 11 mg/mL (23.46 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (2.13 mM), Sonication is recommended. |
| 關鍵字 | Protein Arginine Deiminase | Peptidylarginine Deiminase | PAD4 | Inhibitor | inhibit | GSK-199 | GSK199 | GSK 199 |
| 相關產品 | BMS-P5 | BMS-P5 free base | BB-Cl-Amidine | PAD-IN-2 | Acefylline | GSK484 hydrochloride | GSK121 | Hydroquinine | N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide | Cl-amidine TFA | KP-302 | Cl-amidine hydrochloride |
| 相關庫 | 抑制劑庫 | 經典已知活性庫 | 抗癌化合物庫 | 已知活性化合物庫 | NO PAINS 化合物庫 | 表觀遺傳庫 | 蛋白翻譯后修飾化合物庫 |
| 成立日期 | 2013-04-18 (14年) | 注冊資本 | 566.265100萬人民幣 |
| 員工人數 | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
| 主營行業(yè) | 天然產物,生化試劑,分子生物學,分子砌塊,生物技術服務 | 經營模式 | 貿易,工廠,試劑,定制,服務 |
| 產品名稱 | 價格 | 公司名稱 | 報價日期 | |
|---|---|---|---|---|
| 詢價 |
河北冀肽生物科技有限公司
|
2026-07-27 | ||
| 詢價 |
VIP1年
|
海南瀚海致遠生物科技有限公司
|
2026-06-10 | |
| 詢價 |
VIP8年
|
廣州市桐暉藥業(yè)有限公司
|
2026-06-02 |