| 中文名稱:瓜子金皂苷己 | 英文名稱:Polygalasaponin F |
| CAS:882664-74-6 | 品牌: TargetMol |
| 產(chǎn)地: 美國 | 保存條件: Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 純度規(guī)格: 99.73% | 產(chǎn)品類別: 抑制劑 |
| 貨號: T006|T3826 |
| 名稱 | Polygalasaponin F |
| 描述 | Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway. |
| 存儲條件 | Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (1.83 mM), Sonication is recommended. DMSO : 60 mg/mL (54.98 mM), Sonication is recommended. |
| 關(guān)鍵字 | Toll-like Receptor (TLR) | TLR | Protein kinase B | Polygalasaponin F | PKB | PI3K | Phosphoinositide 3-kinase | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | Akt |
| 相關(guān)產(chǎn)品 | D-Psicose | Sodium propionate | Aceglutamide | 5-Aminosalicylic Acid | Hyaluronic acid | Hydroxychloroquine | Zinc chloride | Triphenyl phosphate | Chitin | Kojic acid | Ethyl linoleate | N,N-Dimethylacetamide |
| 相關(guān)庫 | 已知活性化合物庫 | 植物來源化合物庫 | 古代經(jīng)典名方目錄分子庫 | 激酶抑制劑庫 | 抗衰老化合物庫 | 抗癌天然產(chǎn)物庫 | 膜蛋白靶向化合物庫 | 免疫/炎癥分子化合物庫 | 萜類天然產(chǎn)物庫 | 中藥抗炎分子庫 | 糖類及苷類化合物庫 | 高通量篩選天然產(chǎn)物庫 |
| 成立日期 | 2013-04-18 (14年) | 注冊資本 | 566.265100萬人民幣 |
| 員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
| 主營行業(yè) | 天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù) | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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