Human IL-39 Protein, Fc Tag (MALS verified)

分子別名（Synonym）

EBI3,IL39,IL-39EBI3,IL39p19,Interleukin-39,IL-39

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IL-39, Fc Tag (IL9-H5259) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Lys 229 & Arg 20 - Pro 189 (Accession # Q14213-1 (IL-27 beta) & Q9NPF7-1 (IL-23 alpha)).

Predicted N-terminus: Arg 21

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 69.4 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 360 mM NaCl, PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白細(xì)胞介素39（IL-39）是IL-12家族的新成員，由IL-23p19和Ebi3亞基組成。IL-23p19和Ebi3這兩個亞基與IL-23和IL-27/IL-35共享。IL-23p19是一個四螺旋面包，與IL-6和粒細(xì)胞集落刺激因子具有同源性。Ebi3首先在感染EB病毒的B淋巴細(xì)胞中鑒定出來。一些研究報告稱，IL-23R和gp130的組合形成了IL-39受體。目前，對IL-39的研究還處于起步階段，許多問題尚未得到解決。