Human BMP-4 / BMP2B (improved sequence) Protein, premium grade
分子別名（Synonym）
BMP4,BMP2B,BMP2B1,MCOPS6,OFC11,ZYME
表達區(qū)間及表達系統(tǒng)（Source）
Human BMP-4 (improved sequence) Protein, premium grade (BM4-H5118) is expressed from E. coli cells. It is a variant of BMP-4 to suit cell culture applications better.
Predicted N-terminus: Met
該產品是在我們嚴格的質量控制體系下生產的，該體系包含一套全面的測試，包括無菌和內毒素測試。在早期臨床前階段，產品性能經過仔細驗證和測試，以確保其與細胞培養(yǎng)用途或任何其他應用的兼容性。
GMP-BM4H18是BM4-H5118的GMP版本。這兩種蛋白質顯示出無法區(qū)分的性能特征，從而確保最終用戶從早期臨床前階段無縫過渡到后期臨床階段。
蛋白結構（Molecular Characterization）
This protein carries no "tag".
The protein has a calculated MW of 13.2 kDa. The protein migrates as 13 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
內毒素（Endotoxin）
Less than 0.05 EU per μg by the LAL method.
宿主蛋白殘留（Host Cell Protein）
<0.5 ng/μg of protein tested by ELISA.
宿主核酸殘留（Host Cell DNA）
<0.02 ng/μg of protein tested by qPCR.
無菌（Sterility）
Negative
支原體（Mycoplasma）
Negative.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH2.2 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
Bone Morphogenetic Protein 4 (BMP4) is a member of growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. BMP-4 Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. BMP-4 can acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
關鍵字： BMP-4;BMP-4蛋白;BMP-4重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。