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SLC2A3抗體,Rabbit Polyclonal SLC2A3 Antibody
  • SLC2A3抗體,Rabbit Polyclonal SLC2A3 Antibody
  • SLC2A3抗體,Rabbit Polyclonal SLC2A3 Antibody
  • SLC2A3抗體,Rabbit Polyclonal SLC2A3 Antibody

Rabbit Polyclonal SLC2A3 Antibody

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SLC2A3抗體英文名稱:Rabbit Polyclonal SLC2A3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 35 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SLC2A3
2025-05-09 SLC2A3抗體 Rabbit Polyclonal SLC2A3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 35 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGLUT3
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human SLC2A3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human colorectal cancer tissue lysate, Primary antibody: P03994(SLC2A3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03994(SLC2A3 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻

1. **"SLC2A3 (GLUT3) as a Potential Prognostic Marker in Colorectal Cancer"**

- *Author(s): Chen L, et al.*

- **摘要**: 該研究使用SLC2A3抗體通過免疫組化和Western blot分析結(jié)直腸癌組織中GLUT3蛋白的表達,發(fā)現(xiàn)其高表達與腫瘤轉(zhuǎn)移和不良預(yù)后顯著相關(guān),提示GLUT3可能作為癌癥治療的潛在靶點。

2. **"Validation of a Novel Anti-SLC2A3 Antibody for Immunohistochemical Detection in Neurological Tissues"**

- *Author(s): Müller T, et al.*

- **摘要**: 研究驗證了一種新型SLC2A3抗體的特異性,通過siRNA敲低實驗和質(zhì)譜分析確認其識別GLUT3蛋白,成功應(yīng)用于小鼠腦組織的免疫熒光染色,顯示其在神經(jīng)元中的高表達定位。

3. **"SLC2A3 Modulates Insulin Sensitivity via Glucose Uptake in Adipocytes"**

- *Author(s): Park S, et al.*

- **摘要**: 利用SLC2A3抗體研究脂肪細胞中GLUT3的功能,發(fā)現(xiàn)其表達受胰島素調(diào)控,敲低GLUT3導(dǎo)致葡萄糖攝取減少,提示其在代謝紊亂(如糖尿病)中的調(diào)控作用。

4. **"GLUT3 Overexpression in Hypoxic Tumors Promotes Chemoresistance"**

- *Author(s): Gupta K, et al.*

- **摘要**: 通過SLC2A3抗體的Western blot和流式細胞術(shù),發(fā)現(xiàn)缺氧腫瘤微環(huán)境中GLUT3表達上調(diào),增強癌細胞葡萄糖代謝,導(dǎo)致化療耐藥性,靶向GLUT3可逆轉(zhuǎn)此效應(yīng)。

(注:以上文獻信息為模擬生成,實際引用需以真實文獻為準。)

       

背景信息

The SLC2A3 antibody is a research tool designed to detect the solute carrier family 2 member 3 (SLC2A3), also known as glucose transporter 3 (GLUT3). Encoded by the SLC2A3 gene, GLUT3 is a transmembrane protein responsible for facilitating glucose uptake across cell membranes. Predominantly expressed in neurons, GLUT3 ensures high-affinity glucose transport to meet the brain’s substantial energy demands. It also plays roles in other tissues, including the placenta, sperm, and certain cancer cells, where glucose metabolism is critical for function or proliferation.

SLC2A3 antibodies are widely used in biomedical research to study GLUT3 expression patterns, localization, and regulation under physiological or pathological conditions. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GLUT3’s involvement in diseases such as Alzheimer’s, diabetes, and cancers, where altered glucose metabolism is a hallmark. For instance, upregulated GLUT3 in tumors is associated with aggressive growth and poor prognosis, making it a potential therapeutic target.

Antibody specificity is validated using knockout controls or siRNA-mediated gene silencing to confirm binding to the 55 kDa GLUT3 protein. Researchers select SLC2A3 antibodies based on host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and applications. Proper validation ensures reliable detection, critical for studies exploring metabolic dysregulation or developing diagnostic biomarkers. Overall, SLC2A3 antibodies are indispensable for dissecting glucose transport mechanisms and their implications in health and disease.

       
關(guān)鍵字: SLC2A3抗體;SLC2A3;SLC2A3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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