Rabbit Polyclonal ITGAX Antibody

價(jià)格	詢價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	湖北
更新日期	2025-05-09

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產(chǎn)品詳情

中文名稱:ITGAX抗體	英文名稱:Rabbit Polyclonal ITGAX Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 69 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無(wú)	靶點(diǎn): ITGAX

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	1/15-1/50	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	咨詢技術(shù)	Human,Mouse,Rat
Elisa	1/1000-1/2000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	PDGF1; PDGF-A
Entrez GeneID	5154
clone	4C1D6
WB Predicted band size	24kDa
Host/Isotype	Mouse IgG2a
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Purified recombinant fragment of human PDGFA (AA: 87-211) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

+ +

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Immunofluorescence analysis of Hela cells using PDGFA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Immunofluorescence analysis of NIH/3T3 cells using PDGFA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Flow cytometric analysis of Jurkat cells using PDGFA mouse mAb (green) and negative control (red).

參考文獻(xiàn)

以下是3-4條關(guān)于ITGAX抗體的參考文獻(xiàn)示例(內(nèi)容為模擬，僅供參考)：

1. **"ITGAX (CD11c) as a specific marker for dendritic cell subsets in human tissues"**

- **作者**: Schmid, M.A., Caux, C.

- **摘要**: 研究驗(yàn)證了ITGAX抗體在識(shí)別人類組織中樹(shù)突狀細(xì)胞(DCs)亞群的特異性，發(fā)現(xiàn)其在炎癥和穩(wěn)態(tài)條件下的表達(dá)差異，支持其作為DCs標(biāo)記物的應(yīng)用。

2. **"Targeting ITGAX in cancer-associated fibroblasts inhibits tumor growth in a murine model"**

- **作者**: Hegde, S., et al.

- **摘要**: 通過(guò)ITGAX抗體阻斷腫瘤相關(guān)成纖維細(xì)胞(CAFs)中的整合素αX信號(hào)通路，顯著抑制小鼠模型中腫瘤的生長(zhǎng)和轉(zhuǎn)移，提示其作為潛在治療靶點(diǎn)。

3. **"ITGAX-mediated leukocyte adhesion in autoimmune lupus nephritis"**

- **作者**: Hirose, S., et al.

- **摘要**: 利用ITGAX抗體研究系統(tǒng)性紅斑狼瘡(SLE)模型，發(fā)現(xiàn)ITGAX通過(guò)促進(jìn)白細(xì)胞粘附和浸潤(rùn)加劇腎臟炎癥，為自身免疫疾病機(jī)制提供新見(jiàn)解。

4. **"Optimization of ITGAX antibody for flow cytometry: Implications for immune profiling"**

- **作者**: Hamblin, T.J., et al.

- **摘要**: 探討不同克隆號(hào)ITGAX抗體在流式細(xì)胞術(shù)中的應(yīng)用效果，優(yōu)化染色條件以提高免疫細(xì)胞分型的準(zhǔn)確性，尤其在血液樣本中的實(shí)用性。

(注：以上文獻(xiàn)為示例，實(shí)際引用時(shí)需檢索真實(shí)數(shù)據(jù)庫(kù)如PubMed獲取準(zhǔn)確信息。)

背景信息

ITGAX, also known as integrin alpha X or CD11c, is a transmembrane protein that forms the α-subunit of the heterodimeric integrin receptor αXβ2 (CR4). It pairs with the β2 subunit (CD18) to mediate cell-cell and cell-extracellular matrix interactions, primarily in immune responses. ITGAX is highly expressed on the surface of dendritic cells, monocytes, macrophages, and a subset of activated lymphocytes, playing a critical role in leukocyte adhesion, migration, and phagocytosis. Its ligands include ICAM-1. fibrinogen, and iC3b, facilitating pathogen recognition, immune surveillance, and inflammatory processes.

Antibodies targeting ITGAX (CD11c) are widely used in research to identify and isolate dendritic cells and myeloid cell populations in tissues or circulation. They serve as key tools in flow cytometry, immunohistochemistry, and functional studies to dissect immune cell behavior in homeostasis and disease. In pathological contexts, ITGAX expression is linked to chronic inflammation, autoimmune disorders (e.g., lupus, multiple sclerosis), and cancer. For example, tumor-associated macrophages expressing CD11c may correlate with tumor progression or immune modulation.

Recent studies explore ITGAX antibodies for therapeutic applications, such as blocking leukocyte infiltration in inflammatory diseases or enhancing antigen presentation in immunotherapy. Their specificity makes them valuable for both diagnostic and experimental investigations into immune regulation and targeted therapies.

關(guān)鍵字： ITGAX抗體;ITGAX;ITGAX Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力，擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新，產(chǎn)品創(chuàng)新和管理創(chuàng)新，贏得了國(guó)內(nèi)外廣大用戶的信任。

成立日期	2024-06-24 （2年）	注冊(cè)資本	50萬(wàn)(元)
員工人數(shù)	1-10人	年?duì)I業(yè)額	￥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè)	中間體,化學(xué)試劑	經(jīng)營(yíng)模式	貿(mào)易,工廠,試劑,定制,服務(wù)

湖北瑞和寧生物科技有限公司

普通會(huì)員

公司成立：2年
注冊(cè)資本：50萬(wàn)(元)
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：中間體。試劑
公司地址：江漢區(qū)

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