Rabbit Polyclonal GRIA1 Antibody

價格	詢價
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	湖北
更新日期	2025-05-09

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產(chǎn)品詳情

中文名稱:GRIA1抗體	英文名稱:Rabbit Polyclonal GRIA1 Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 92 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Rabbit
偶聯(lián)物: 無	靶點: GRIA1

驗證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	1/25-1/100	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	咨詢技術(shù)	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	GLUH1; GLUR1; GLURA; GluA1; HBGR1
WB Predicted band size	102 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human GRIA1
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Rat brain tissue and Mouse brain tissue lysates, Primary antibody: P04152(GRIA1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04152(GRIA1 Antibody) at dilution 1/25. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04152(GRIA1 Antibody) at dilution 1/25. (Original magnification: ×200)

參考文獻

以下是3-4篇與GRIA1(GluA1)抗體相關(guān)的研究文獻摘要簡述：

1. **文獻名稱**：*AMPA receptor trafficking and synaptic plasticity*

**作者**：Shepherd JD, Huganir RL

**摘要**：該綜述討論了AMPA受體(如GluA1/GRIA1)的轉(zhuǎn)運機制及其在突觸可塑性中的作用，其中提到使用特異性GRIA1抗體驗證受體在神經(jīng)元中的定位及表達變化。

2. **文獻名稱**：*Phosphorylation of the AMPA receptor GluA1 subunit regulates synaptic plasticity*

**作者**：Lee HK, Kameyama K, et al.

**摘要**：研究通過GRIA1磷酸化特異性抗體(如Ser831位點)揭示GluA1磷酸化對長時程增強(LTP)的調(diào)控，證實其在突觸強度調(diào)節(jié)中的關(guān)鍵作用。

3. **文獻名稱**：*GluA1 downregulation in Alzheimer's disease: an antibody-based proteomic analysis*

**作者**：Chang EH, Savage MJ, et al.

**摘要**：利用GRIA1抗體進行腦組織蛋白質(zhì)組學(xué)分析，發(fā)現(xiàn)阿爾茨海默病患者海馬區(qū)GluA1表達顯著降低，提示其與認知衰退相關(guān)。

4. **文獻名稱**：*Antibody validation for specificity in Western blotting: a case study on anti-GluA1 antibodies*

**作者**：Herbert K, Collingridge GL

**摘要**：系統(tǒng)評估了多種市售GRIA1抗體的特異性，通過敲除模型驗證抗體在Western blot和免疫組化中的可靠性，為實驗選擇提供依據(jù)。

(注：以上文獻名為示例概括，實際文獻需通過PubMed或期刊數(shù)據(jù)庫檢索具體標題及作者。)

背景信息

The GRIA1 antibody targets the glutamate ionotropic receptor AMPA type subunit 1 (GluA1), a critical component of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. These ligand-gated ion channels mediate the majority of fast excitatory synaptic transmission in the central nervous system. GluA1. encoded by the GRIA1 gene, forms tetrameric complexes with other AMPA receptor subunits (GluA2-4) to regulate synaptic plasticity, learning, and memory. Its function is modulated by post-translational modifications, trafficking, and interactions with scaffolding proteins.

GRIA1 antibodies are widely used in neuroscience research to study GluA1 expression, localization, and dynamics in neuronal tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into synaptic strength, long-term potentiation (LTP), and neurological disorders. Dysregulation of GluA1 has been implicated in conditions such as Alzheimer’s disease, epilepsy, and schizophrenia, making these antibodies valuable for mechanistic and diagnostic studies. Specific GRIA1 antibodies are validated for species reactivity (e.g., human, mouse, rat) and application-specific performance. Researchers also utilize them to explore therapeutic targets, as AMPA receptor modulation holds potential for treating cognitive deficits and neurodegenerative diseases. Proper controls, including knockout validation, are essential to ensure antibody specificity given structural similarities among AMPA receptor subunits.

關(guān)鍵字： GRIA1抗體;GRIA1;GRIA1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力，擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新，產(chǎn)品創(chuàng)新和管理創(chuàng)新，贏得了國內(nèi)外廣大用戶的信任。

成立日期	2024-06-24 （3年）	注冊資本	50萬(元)
員工人數(shù)	1-10人	年營業(yè)額	￥ 100萬以內(nèi)
主營行業(yè)	中間體,化學(xué)試劑	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

湖北瑞和寧生物科技有限公司

普通會員

公司成立：3年
注冊資本：50萬(元)
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：中間體。試劑
公司地址：江漢區(qū)

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