| 價(jià)格 | 詢價(jià) | ||
| 包裝 | 20μl | 50μl | 100μl |
| 最小起訂量 | 1μl |
| 發(fā)貨地 | 湖北 |
| 更新日期 | 2025-05-09 |
| 中文名稱:TRAF7抗體 | 英文名稱:Rabbit Polyclonal TRAF7 Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 122 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
| 偶聯(lián)物: 無(wú) | 靶點(diǎn): TRAF7 |
| WB | 咨詢技術(shù) | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | RFWD1, RNF119 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRAF7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: P04225(TRAF7 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04225(TRAF7 Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04225(TRAF7 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于TRAF7抗體的3篇代表性文獻(xiàn)的簡(jiǎn)要概括(文獻(xiàn)標(biāo)題、作者及摘要內(nèi)容均為示例,實(shí)際文獻(xiàn)可能需要根據(jù)具體數(shù)據(jù)庫(kù)檢索確認(rèn)):
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1. **文獻(xiàn)名稱**:*TRAF7 mutations in craniopharyngioma and antibody validation*
**作者**:E.G. Ortiz-Sánchez, et al.
**摘要**:本研究通過免疫組化和Western blot驗(yàn)證了TRAF7抗體在顱咽管瘤組織中的特異性,發(fā)現(xiàn)TRAF7突變導(dǎo)致其與β-catenin通路的異?;プ?,抗體可用于突變蛋白的病理檢測(cè)。
2. **文獻(xiàn)名稱**:*TRAF7 functions as a tumor suppressor via regulating NF-κB signaling*
**作者**:M. Sánchez-Tilló, et al.
**摘要**:利用TRAF7抗體進(jìn)行蛋白質(zhì)互作分析,揭示TRAF7作為泛素連接酶通過降解特定激酶抑制NF-κB通路,抗體在體外實(shí)驗(yàn)中有效識(shí)別內(nèi)源性TRAF7蛋白。
3. **文獻(xiàn)名稱**:*TRAF7 antibody application in cardiac fibrosis research*
**作者**:H. Chen, et al.
**摘要**:研究報(bào)道TRAF7在心臟纖維化中的表達(dá)上調(diào),通過免疫沉淀和抗體阻斷實(shí)驗(yàn)證明其通過TAK1調(diào)控心肌細(xì)胞凋亡,相關(guān)抗體為疾病標(biāo)志物研究提供工具。
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**注**:以上文獻(xiàn)為示例,實(shí)際文獻(xiàn)需通過PubMed、Google Scholar等平臺(tái)以“TRAF7 antibody”或“TRAF7 function”為關(guān)鍵詞檢索。部分真實(shí)文獻(xiàn)可能側(cè)重抗體開發(fā)(如抗體驗(yàn)證方法)或疾病機(jī)制研究(如癌癥、罕見病)。
**Background of TRAF7 Antibody**
TRAF7 (TNF receptor-associated factor 7) is a member of the TRAF protein family, which plays roles in intracellular signaling pathways, including NF-κB and MAPK regulation. Unlike other TRAF proteins, TRAF7 uniquely combines a RING domain with WD40 repeats, functioning as an E3 ubiquitin ligase and scaffolding protein. It is implicated in diverse cellular processes, such as apoptosis, immune response, and stress signaling. TRAF7 mutations or dysregulation are linked to cancers (e.g., meningiomas, gliomas) and rare genetic disorders like cardiofaciocutaneous syndrome.
TRAF7 antibodies are essential tools for detecting TRAF7 expression in research, enabling studies on its molecular mechanisms and disease associations. These antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein localization, expression levels, and interactions. Commercially available TRAF7 antibodies are typically validated for specificity against human or murine isoforms. Recent studies highlight TRAF7's role in tumorigenesis and its potential as a therapeutic target, driving demand for reliable antibodies to explore its functional pathways and clinical relevance. Understanding TRAF7's signaling dynamics through antibody-based assays contributes to insights into cancer biology and rare developmental disorders.
| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(wàn)(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
| 主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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