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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human stomach tissue lysate, Primary antibody: P04448(SCTR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04448(SCTR Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

Secretin receptor (SCTR) antibodies are tools used to study the secretin receptor, a class B G protein-coupled receptor (GPCR) that plays a critical role in regulating digestive and metabolic processes. SCTR is activated by secretin, a peptide hormone released by intestinal S-cells in response to acidic chyme. Upon activation, SCTR triggers intracellular signaling pathways (primarily cAMP/PKA) to modulate pancreatic bicarbonate secretion, gastric acid neutralization, and bile flow. Dysregulation of SCTR signaling has been implicated in gastrointestinal disorders, cholestasis, and neuroendocrine tumors.

SCTR antibodies are designed to detect and quantify receptor expression, localization, and function in research settings. They enable studies on receptor trafficking, ligand-receptor interactions, and pathological mechanisms. Polyclonal and monoclonal antibodies targeting specific epitopes (e.g., extracellular or intracellular domains) are utilized in techniques like immunohistochemistry, Western blotting, and flow cytometry. Some antibodies also serve as antagonists or agonists to probe receptor activity. Recent interest in SCTR-targeted therapies for diseases like pancreatitis or liver fibrosis has spurred the development of diagnostic and therapeutic antibodies. However, challenges remain in ensuring specificity and minimizing cross-reactivity with other GPCRs due to structural similarities. Ongoing research aims to refine SCTR antibody applications for both basic science and clinical translation.