+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04582(SHROOM2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04582(SHROOM2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SHROOM2 antibody is a tool used to detect SHROOM2. a protein encoded by the SHROOM2 gene, which belongs to the SHROOM family of actin-binding proteins. SHROOM proteins regulate cell shape and polarity by modulating cytoskeletal dynamics. SHROOM2. specifically, plays a role in neural tube closure, eye development, and epithelial morphogenesis by interacting with Rho kinase (ROCK1) to promote actomyosin contractility. It is expressed in various tissues, including the nervous system, retina, and melanocytes.

Antibodies targeting SHROOM2 are utilized in research to investigate its localization, expression levels, and functional roles in developmental processes and disease contexts. For example, studies employ SHROOM2 antibodies in techniques like Western blotting, immunohistochemistry, or immunofluorescence to assess protein distribution in tissues or cultured cells. Aberrant SHROOM2 expression has been implicated in pathologies such as melanoma and neuroblastoma, making it a potential biomarker or therapeutic target.

Commercial SHROOM2 antibodies are typically validated for specificity via knockout controls or siRNA knockdown. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to other SHROOM family members (e.g., SHROOM3 or SHROOM4). Understanding SHROOM2's role in cytoskeletal regulation and tissue patterning continues to drive interest in developing reliable detection tools for mechanistic and translational studies.