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SIRT1抗體,Mouse Monoclonal SIRT1 Antibody
  • SIRT1抗體,Mouse Monoclonal SIRT1 Antibody
  • SIRT1抗體,Mouse Monoclonal SIRT1 Antibody
  • SIRT1抗體,Mouse Monoclonal SIRT1 Antibody

SIRT1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產品詳情

中文名稱:SIRT1抗體英文名稱:Mouse Monoclonal SIRT1 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 317 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯物: 靶點: SIRT1
2025-05-09 SIRT1抗體 Mouse Monoclonal SIRT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 317 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesSIR2L1; SIRT1
Entrez GeneID23411
clone1F3
WB Predicted band size120kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit,Monkey
ImmunogenPurified recombinant fragment of human SIRT1 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

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       Western blot analysis using SIRT1 mouse mAb against MCF-7 (1), Jurkat (2), Hela (3), HEK293 (4) and A549 (5) cell lysate.    


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       Western blot analysis using SIRT1 mouse mAb against L1210(1),F9,(2),Hela(3) cell lysate.    


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       Immunofluorescence analysis of NTERA-2 cells using SIRT1 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of K562 cells using SIRT1 mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues (left) and kidney cancer tissues (right) using SIRT1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse testis(A)Mouse kidney(B) using SIRT1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat spleen(A)Rat liver(B) using SIRT1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit spleen(A)Rabbit liver(B) using SIRT1 mouse mAb with DAB staining.    


           

參考文獻

以下是3篇關于SIRT1抗體的參考文獻,包含文獻名稱、作者及摘要關鍵內容:

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1. **文獻名稱**: *SIRT1 Deacetylase Protects Against Neurodegeneration in Models for Alzheimer’s Disease and Amyotrophic Lateral Sclerosis*

**作者**: Kim D, et al.

**摘要**: 本研究使用兔源多克隆SIRT1抗體(Cell Signaling Technology #2493)進行免疫印跡和免疫組化,驗證了SIRT1在小鼠神經元中的表達及其在神經退行性疾病中的保護作用??贵w特異性通過SIRT1敲除小鼠腦組織驗證。

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2. **文獻名稱**: *Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival*

**作者**: Yang T, et al.

**摘要**: 作者采用小鼠單克隆SIRT1抗體(Santa Cruz Biotechnology sc-74465)進行免疫沉淀和ChIP實驗,揭示了SIRT1通過去乙?;€粒體蛋白調控能量代謝??贵w驗證包括siRNA敲降后的信號消失實驗。

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3. **文獻名稱**: *SIRT1 Regulates the Histone Methyl-Transferase SUV39H1 During Heterochromatin Formation*

**作者**: Vaquero A, et al.

**摘要**: 研究使用兔多克隆SIRT1抗體(Abcam ab12193)進行免疫熒光和Western blot,證實SIRT1與異染色質形成的關系??贵w的特異性通過肽段競爭實驗驗證,適用于哺乳動物細胞模型。

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**備注**:以上文獻均強調了SIRT1抗體的應用場景(如Western blot、免疫組化、ChIP)及嚴格的抗體驗證方法(如基因敲除/敲降、肽段阻斷),可作為實驗選擇的參考依據。

       

背景信息

SIRT1 (silent mating type information regulation 2 homolog 1) is a NAD?-dependent deacetylase belonging to the sirtuin family, playing critical roles in aging, metabolism, stress response, and genomic stability. It regulates gene expression and cellular pathways by deacetylating histones (e.g., H3K9. H4K16) and non-histone targets like p53. FOXOs, and PGC-1α. Due to its involvement in age-related diseases, cancer, and metabolic disorders, SIRT1 has become a key focus in biomedical research.

SIRT1 antibodies are essential tools for detecting SIRT1 expression, localization, and activity in cells or tissues. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Polyclonal antibodies typically recognize multiple epitopes, offering high sensitivity, while monoclonal antibodies provide specificity for single epitopes. Validation is crucial, as SIRT1 exists in multiple isoforms and post-translational modifications (e.g., phosphorylation) may affect antibody binding. High-quality antibodies are validated using knockout controls or siRNA-mediated knockdown to confirm target specificity.

Research applications include studying SIRT1's roles in caloric restriction, oxidative stress, inflammation, and neurodegenerative diseases (e.g., Alzheimer’s). Commercial antibodies often specify reactivity across species (human, mouse, rat) and provide application-specific recommendations. Proper controls and optimization are necessary to avoid cross-reactivity with other sirtuins (SIRT2-7) or nonspecific signals.

       
關鍵字: SIRT1抗體;SIRT1;SIRT1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
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