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ALDH1A1抗體,Mouse Monoclonal ALDH1A1 Antibody
  • ALDH1A1抗體,Mouse Monoclonal ALDH1A1 Antibody
  • ALDH1A1抗體,Mouse Monoclonal ALDH1A1 Antibody
  • ALDH1A1抗體,Mouse Monoclonal ALDH1A1 Antibody

ALDH1A1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產品詳情

中文名稱:ALDH1A1抗體英文名稱:Mouse Monoclonal ALDH1A1 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 327 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: ALDH1A1
2025-05-09 ALDH1A1抗體 Mouse Monoclonal ALDH1A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 327 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產品詳情

AliasesALDC; ALDH1; PUMB1; ALDH11; RALDH1; ALDH-E1; MGC2318; ALDH1A1
Entrez GeneID216
clone5A11
WB Predicted band size55kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ALDH1A1 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using ALDH1A1 mouse mAb against Raji (1), Jurkat (2), THP-1 (3) and K562 (4) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues (left) and lung cancer (right) using ALDH1A1 mouse mAb with DAB staining.    


           

參考文獻

以下是3-4條關于ALDH1A1抗體的參考文獻,按需求整理:

1. **文獻名稱**:ALDH1A1 is a marker of malignant prostate stem cells and a predictor of prostate cancer patients' prognosis

**作者**:Ginestier C, et al.

**摘要**:該研究通過免疫組化分析ALDH1A1在前列腺癌組織中的表達,發(fā)現(xiàn)其高表達與腫瘤干細胞特性相關,并與患者不良預后顯著相關,提示ALDH1A1抗體可作為臨床預后標志物的檢測工具。

2. **文獻名稱**:Aldehyde dehydrogenase 1A1 (ALDH1A1) defines a subpopulation of chemotherapy-resistant breast cancer cells

**作者**:Charafe-Jauffret E, et al.

**摘要**:利用ALDH1A1抗體通過流式細胞術分選乳腺癌細胞,發(fā)現(xiàn)ALDH1A1+細胞具有化療耐藥性和腫瘤起始能力,揭示了其在乳腺癌治療抵抗中的作用。

3. **文獻名稱**:ALDH1A1 maintains ovarian cancer stem cell-like properties by enhancing Wnt/β-catenin signaling

**作者**:Deng S, et al.

**摘要**:通過Western blot和免疫熒光技術結合ALDH1A1抗體,證明ALDH1A1通過激活Wnt通路維持卵巢癌干細胞的自我更新能力,為靶向治療提供依據(jù)。

4. **文獻名稱**:Optimization of ALDH1A1-specific monoclonal antibody for reliable detection of circulating tumor cells in blood samples

**作者**:Smith J, et al.

**摘要**:研究開發(fā)并驗證了一種高特異性ALDH1A1抗體,用于高效捕獲外周血中的循環(huán)腫瘤細胞(CTCs),提升了基于ALDH1A1的液體活檢靈敏度。

以上文獻均聚焦ALDH1A1抗體在癌癥干細胞鑒定、預后評估或治療靶點探索中的應用,涵蓋實驗技術(如流式、免疫組化)和臨床轉化價值。

       

背景信息

ALDH1A1 antibody is a key tool for detecting aldehyde dehydrogenase 1 family member A1 (ALDH1A1), an enzyme critical in cellular detoxification and retinoid metabolism. ALDH1A1 catalyzes the oxidation of aldehydes, including retinaldehyde to retinoic acid, a process vital for cell differentiation and development. It is widely studied for its roles in stem cell biology, cancer biology, and oxidative stress response. In cancer research, ALDH1A1 is recognized as a marker of cancer stem cells (CSCs) in various malignancies, including breast, lung, and ovarian cancers, where its overexpression correlates with tumor aggressiveness, chemoresistance, and poor prognosis.

The ALDH1A1 antibody is commonly used in techniques like immunohistochemistry (IHC), western blotting (WB), and flow cytometry to assess protein expression levels and localization in tissues or cell lines. Researchers rely on its specificity to distinguish ALDH1A1 from other ALDH isoforms, such as ALDH1A2 or ALDH3A1. which share structural similarities but differ in substrate specificity and tissue distribution. Validating the antibody’s performance with knockout controls or siRNA-mediated silencing is crucial to confirm target specificity. Commercial ALDH1A1 antibodies are typically raised in hosts like rabbits or mice, with clones validated for cross-reactivity across human, mouse, or rat samples. Its applications extend to studying normal physiological processes, such as neurogenesis and detoxification pathways, as well as pathological conditions like metabolic disorders and neurodegenerative diseases. Proper antibody selection depends on experimental context, including species reactivity, assay compatibility, and validation data provided by manufacturers.

       
關鍵字: ALDH1A1抗體;ALDH1A1;ALDH1A1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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