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CRTC3抗體,Mouse Monoclonal CRTC3 Antibody
  • CRTC3抗體,Mouse Monoclonal CRTC3 Antibody
  • CRTC3抗體,Mouse Monoclonal CRTC3 Antibody
  • CRTC3抗體,Mouse Monoclonal CRTC3 Antibody

CRTC3抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CRTC3抗體英文名稱:Mouse Monoclonal CRTC3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 374 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): CRTC3
2025-05-09 CRTC3抗體 Mouse Monoclonal CRTC3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 374 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Monkey
IF咨詢技術(shù) Human,Monkey
IHC1/200 - 1/1000 Human,Monkey
ICC1/200 - 1/1000 Human,Monkey
FCM咨詢技術(shù) Human,Monkey
Elisa1/10000 Human,Monkey
   

產(chǎn)品詳情

AliasesTORC3; FLJ21868; CRTC3
Entrez GeneID64784
clone5G9
WB Predicted band size68kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Monkey
ImmunogenPurified recombinant fragment of human CRTC3 expressed in E. Coli.
FormulationAscitic fluid containing 0.03% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using CRTC3 mouse mAb against Hela (1), Jurkat (2), Cos7 (3) and MCF-7 (4) cell lysate.    


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       Immunofluorescence analysis of NTERA-2 cells using CRTC3 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer (left) and ovarian cancer (right) using CRTC3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right) using CRTC3 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇涉及CRTC3抗體的參考文獻(xiàn)及簡(jiǎn)要摘要:

1. **文獻(xiàn)名稱**:*"CRTC3 regulates catecholamine secretion by controlling tyrosine hydroxylase gene transcription"*

**作者**:Screaton RA et al.

**摘要**:該研究利用CRTC3特異性抗體進(jìn)行免疫印跡和免疫組化,發(fā)現(xiàn)CRTC3通過(guò)調(diào)控酪氨酸羥化酶(TH)基因轉(zhuǎn)錄,影響腎上腺髓質(zhì)細(xì)胞的兒茶酚胺分泌。

2. **文獻(xiàn)名稱**:*"CRTC3 links maternal high-fat diet to lipid accumulation and insulin resistance in skeletal muscle"*

**作者**:Song NJ et al.

**摘要**:通過(guò)CRTC3抗體檢測(cè)小鼠骨骼肌中CRTC3蛋白表達(dá),研究揭示母體高脂飲食通過(guò)CRTC3依賴性通路促進(jìn)肌肉脂質(zhì)堆積和胰島素抵抗。

3. **文獻(xiàn)名稱**:*"Differential regulation of CRTC3 isoforms in adipose tissue remodeling"*

**作者**:Liu Z et al.

**摘要**:研究采用CRTC3抗體區(qū)分其不同亞型,發(fā)現(xiàn)CRTC3-L和CRTC3-S在脂肪組織分化及炎癥反應(yīng)中發(fā)揮相反作用,為代謝疾病提供新機(jī)制見(jiàn)解。

注:以上為示例性內(nèi)容,實(shí)際文獻(xiàn)需通過(guò)PubMed或Google Scholar以關(guān)鍵詞“CRTC3 antibody”或“CRTC3 immunoblot”檢索具體文章。

       

背景信息

The CRTC3 (CREB-regulated transcription coactivator 3) antibody is a tool used to study the CRTC3 protein, a member of the CRTC family (CRTC1. CRTC2. CRTC3) that regulates CREB (cAMP response element-binding protein)-mediated transcriptional activity. CRTC proteins act as coactivators, bridging CREB with the basal transcription machinery to modulate genes involved in stress responses, metabolism, and energy homeostasis. CRTC3. specifically, is highly expressed in adipose tissue, liver, and skeletal muscle, where it plays a critical role in metabolic regulation, including lipogenesis, gluconeogenesis, and insulin signaling. Dysregulation of CRTC3 has been linked to obesity, diabetes, and metabolic syndrome, making it a focus in metabolic disease research.

CRTC3 antibodies are designed to detect endogenous CRTC3 protein in applications such as Western blotting, immunohistochemistry, and immunofluorescence. They help investigate CRTC3’s subcellular localization, post-translational modifications (e.g., phosphorylation), and interactions with signaling pathways like cAMP, AMPK, or mTOR. CRTC3 is regulated by cellular energy status; under low-energy conditions, it translocates to the nucleus to activate target genes. Antibodies targeting specific domains or phosphorylation sites (e.g., Ser391) are essential for studying its functional states. Researchers also use these antibodies to explore CRTC3’s role in cancer, where its aberrant expression may promote tumor growth. Validation of CRTC3 antibodies includes testing in knockout models or siRNA-treated cells to confirm specificity, as cross-reactivity with other CRTC family members can occur. Proper controls are critical for accurate interpretation in experimental models.

       
關(guān)鍵字: CRTC3抗體;CRTC3;CRTC3 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:3年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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