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CCND3抗體,Mouse Monoclonal CCND3 Antibody
  • CCND3抗體,Mouse Monoclonal CCND3 Antibody
  • CCND3抗體,Mouse Monoclonal CCND3 Antibody
  • CCND3抗體,Mouse Monoclonal CCND3 Antibody

CCND3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CCND3抗體英文名稱:Mouse Monoclonal CCND3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 385 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): CCND3
2025-05-09 CCND3抗體 Mouse Monoclonal CCND3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 385 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCCND3
Entrez GeneID896
clone6H4
WB Predicted band size32kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human CCND3 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using CCND3 mouse mAb against NIH/3T3 (1) and Jurkat (2) cell lysate.    


           

參考文獻(xiàn)

以下是關(guān)于CCND3抗體的3篇參考文獻(xiàn)的簡要信息:

1. **文獻(xiàn)名稱**:*Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) translocation in B-cell malignancies*

**作者**:Sonnenschein H, et al.

**摘要**:該研究揭示了在B細(xì)胞淋巴瘤中,染色體易位t(6;14)導(dǎo)致CCND3基因的異常表達(dá),并通過特異性抗體檢測發(fā)現(xiàn)CCND3蛋白過表達(dá)與疾病進(jìn)展相關(guān),提示其作為潛在治療靶點(diǎn)。

2. **文獻(xiàn)名稱**:*CCND3 overexpression enhances chemoresistance in colorectal cancer via β-catenin stabilization*

**作者**:Li Y, et al.

**摘要**:研究利用CCND3抗體分析結(jié)直腸癌組織,發(fā)現(xiàn)CCND3通過穩(wěn)定β-catenin信號通路促進(jìn)腫瘤細(xì)胞化療耐藥性,高表達(dá)患者預(yù)后較差,為靶向干預(yù)提供依據(jù)。

3. **文獻(xiàn)名稱**:*Cyclin D3 deficiency inhibits T-cell proliferation and leads to developmental defects in mice*

**作者**:Cooper CL, et al.

**摘要**:通過CCND3抗體在敲除小鼠模型中的研究,發(fā)現(xiàn)CCND3缺失導(dǎo)致T細(xì)胞增殖受阻和免疫發(fā)育異常,證實(shí)其在細(xì)胞周期調(diào)控中的關(guān)鍵作用。

以上文獻(xiàn)均圍繞CCND3抗體的應(yīng)用展開,涵蓋腫瘤機(jī)制、耐藥性及免疫調(diào)控等領(lǐng)域。

       

背景信息

CCND3 (Cyclin D3) is a member of the D-type cyclin family, which includes CCND1 and CCND2. These proteins play critical roles in regulating the cell cycle progression from the G1 to S phase by forming complexes with cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6. The activated kinase complexes phosphorylate retinoblastoma (Rb) proteins, leading to the release of E2F transcription factors and subsequent initiation of DNA synthesis. CCND3 is encoded by the *CCND3* gene located on chromosome 6q21 and is expressed in various tissues, with higher levels observed in lymphoid cells and certain epithelial tissues.

Antibodies targeting CCND3 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect CCND3 protein levels in cell lines, tissue samples, or experimental models. Specificity and validation (e.g., knockout cell lines or siRNA-mediated knockdown) are critical to ensure accurate detection, as cross-reactivity with other D-type cyclins can occur.

Dysregulation of CCND3 has been implicated in cancer. While CCND1 is more commonly associated with malignancies (e.g., mantle cell lymphoma via t(11;14) translocation), CCND3 overexpression or genetic alterations are linked to hematopoietic malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and multiple myeloma. Conversely, reduced CCND3 expression has been observed in some solid tumors. Research using CCND3 antibodies continues to explore its dual role as an oncogene or tumor suppressor, depending on cellular context, and its potential as a therapeutic target.

       
關(guān)鍵字: CCND3抗體;CCND3;CCND3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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