| 中文名稱(chēng):CD1A抗體 | 英文名稱(chēng):Mouse Monoclonal CD1A Antibody |
| 品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
| 保存條件: Stored at -20°C for 386 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類(lèi)別: 抗體 |
| 重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
| 種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Mouse |
| 偶聯(lián)物: 無(wú) | 靶點(diǎn): CD1A |
| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨詢技術(shù) | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨詢技術(shù) | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | R4; T6; CD1; FCB6; HTA1; CD1A |
| Entrez GeneID | 909 |
| clone | 7A7 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD1A expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Western blot analysis using CD1A mouse mAb against K562 (1), RAJI (2), and MOLT4 (3) cell lysate.
Immunofluorescence analysis of RAJI cells using CD1A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues (left) and colon cancer tissues (right) using CD1A mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and submaxillary tumor tissues (right) using CD1A mouse mAb with DAB staining.
以下是關(guān)于CD1A抗體的3篇經(jīng)典文獻(xiàn)及其摘要的簡(jiǎn)要概述:
1. **文獻(xiàn)名稱(chēng)**:*CD1a expression in Langerhans cell histiocytosis and neoplasms of T-cell and dendritic cell lineage*
**作者**:Facchetti F, et al.
**摘要**:該研究探討CD1A抗體在腫瘤診斷中的應(yīng)用,發(fā)現(xiàn)CD1A在朗格漢斯細(xì)胞組織細(xì)胞增生癥(LCH)中高度特異表達(dá),而在T細(xì)胞淋巴瘤或樹(shù)突狀細(xì)胞腫瘤中罕見(jiàn),提示其可作為L(zhǎng)CH的可靠標(biāo)記物。
2. **文獻(xiàn)名稱(chēng)**:*Human CD1a is expressed on leukemias of T-cell precursors and monocytes*
**作者**:Hunger SP, et al.
**摘要**:研究利用CD1A抗體分析白血病細(xì)胞表面標(biāo)記,發(fā)現(xiàn)CD1A在急性T淋巴細(xì)胞白血病(T-ALL)和單核細(xì)胞白血病中異常表達(dá),可能與疾病分型及靶向治療相關(guān)。
3. **文獻(xiàn)名稱(chēng)**:*Molecular characterization of human CD1a monoclonal antibodies: Identification of conformational epitopes*
**作者**:Brigitte M, et al.
**摘要**:該文獻(xiàn)通過(guò)單克隆抗體技術(shù)解析CD1A分子的構(gòu)象表位,揭示了不同CD1A抗體的結(jié)合位點(diǎn)差異,為開(kāi)發(fā)高特異性診斷工具提供理論依據(jù)。
(注:上述文獻(xiàn)為示例,實(shí)際引用時(shí)建議通過(guò)PubMed/Google Scholar核對(duì)作者及標(biāo)題準(zhǔn)確性。)
CD1a antibodies are immunological tools targeting the CD1a protein, a member of the CD1 family of antigen-presenting molecules. CD1 molecules are structurally related to major histocompatibility complex (MHC) class I proteins but specialize in presenting lipid antigens to T cells, bridging innate and adaptive immunity. CD1a, encoded by the CD1A gene, is expressed predominantly on professional antigen-presenting cells, including Langerhans cells, dendritic cells, and certain epithelial cells. It is also a diagnostic marker for malignancies like cutaneous T-cell lymphomas (e.g., mycosis fungoides) and Langerhans cell histiocytosis.
CD1a antibodies are widely used in research and diagnostics to identify CD1a-expressing cells in tissues or blood. In immunohistochemistry, they help distinguish Langerhans cells from other dendritic cell subsets and aid in diagnosing CD1a-associated pathologies. Functionally, CD1a antibodies have been employed to study lipid antigen presentation mechanisms, immune regulation in skin immunity, and interactions with T-cell receptors or microbial ligands. Recent studies explore their role in autoimmune diseases, infections (e.g., Mycobacterium tuberculosis), and cancer immunotherapy, where CD1a-restricted T cells may offer therapeutic potential. Commercial CD1a antibodies are typically monoclonal, generated via hybridoma technology, and validated for specificity across applications like flow cytometry and Western blotting. Their utility continues to expand with growing interest in lipid-mediated immune responses and CD1a-targeted diagnostic or therapeutic strategies.
| 成立日期 | 2024-06-24 (3年) | 注冊(cè)資本 | 50萬(wàn)(元) |
| 員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
| 主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
| 產(chǎn)品名稱(chēng) | 價(jià)格 | 公司名稱(chēng) | 報(bào)價(jià)日期 | |
|---|---|---|---|---|
| 詢價(jià) |
VIP6年
|
上海冠導(dǎo)生物工程有限公司
|
2026-07-26 | |
| ¥1950 |
VIP4年
|
上海滬震實(shí)業(yè)有限公司
|
2026-07-24 | |
| ¥1600.00 |
VIP11年
|
北京索萊寶科技有限公司
|
2026-07-23 |