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CDK9抗體,Mouse Monoclonal CDK9 Antibody
  • CDK9抗體,Mouse Monoclonal CDK9 Antibody
  • CDK9抗體,Mouse Monoclonal CDK9 Antibody
  • CDK9抗體,Mouse Monoclonal CDK9 Antibody

CDK9抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):CDK9抗體英文名稱(chēng):Mouse Monoclonal CDK9 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 404 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): CDK9
2025-05-09 CDK9抗體 Mouse Monoclonal CDK9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 404 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesTAK; C-2k; CTK1; CDC2L4; PITALRE
Entrez GeneID1025
clone1B5A7
WB Predicted band size43kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit,Monkey
ImmunogenPurified recombinant fragment of human CDK9 expressed in E. Coli.  
FormulationAscitic fluid containing 0.03% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues (left) and placenta tissues (right) using CDK9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues (left) and esophageal cancer tissues (right) using CDK9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse kidney using CDK9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using CDK9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit kidney using CDK9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit testis using CDK9 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于CDK9抗體的3篇參考文獻(xiàn)示例(內(nèi)容為模擬,僅供參考):

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1. **文獻(xiàn)名稱(chēng)**:*"Development of a Monoclonal Antibody Targeting CDK9 for Transcriptional Regulation Studies"*

**作者**:Smith A. et al.

**摘要**:描述了一種新型CDK9單克隆抗體的開(kāi)發(fā),該抗體能夠特異性識(shí)別CDK9蛋白,并成功應(yīng)用于染色質(zhì)免疫沉淀(ChIP)實(shí)驗(yàn),揭示了CDK9在RNA聚合酶II介導(dǎo)的轉(zhuǎn)錄延伸中的作用。

2. **文獻(xiàn)名稱(chēng)**:*"CDK9 Overexpression in Hepatocellular Carcinoma: Prognostic Implications and Antibody-Based Detection"*

**作者**:Zhang Y. et al.

**摘要**:通過(guò)免疫組化(IHC)分析肝癌組織中CDK9的表達(dá)水平,發(fā)現(xiàn)CDK9高表達(dá)與患者生存率降低顯著相關(guān),提示其可作為預(yù)后標(biāo)志物和治療靶點(diǎn)。

3. **文獻(xiàn)名稱(chēng)**:*"A Phospho-Specific CDK9 Antibody Reveals Activation Dynamics in HIV-1 Infected Cells"*

**作者**:Johnson R. et al.

**摘要**:開(kāi)發(fā)了一種磷酸化特異性CDK9抗體,用于檢測(cè)HIV-1感染后CDK9的活化狀態(tài),證實(shí)其通過(guò)促進(jìn)病毒轉(zhuǎn)錄復(fù)合體(Tat-P-TEFb)的活性驅(qū)動(dòng)病毒復(fù)制。

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**備注**:以上文獻(xiàn)為示例,實(shí)際引用時(shí)請(qǐng)以真實(shí)發(fā)表的論文為準(zhǔn)。建議通過(guò)PubMed或Google Scholar檢索關(guān)鍵詞(如“CDK9 antibody”、“CDK9 inhibitor”或“CDK9 therapeutic target”)獲取最新研究。

       

背景信息

CDK9 (Cyclin-Dependent Kinase 9) is a serine/threonine kinase integral to transcriptional regulation as a component of the positive transcription elongation factor b (P-TEFb) complex. It phosphorylates the C-terminal domain of RNA polymerase II, enabling transcriptional elongation and regulating the expression of genes critical for cell growth, differentiation, and stress responses. CDK9’s role in promoting the transcription of pro-survival and oncogenic proteins, such as MYC and MCL-1. has linked its dysregulation to cancers, viral replication (e.g., HIV), and inflammatory diseases.

CDK9 antibodies are essential tools for studying its expression, localization, and interactions in cellular processes. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess CDK9 protein levels, activation states (e.g., phosphorylation at Thr-186), and association with cyclin partners (e.g., Cyclin T1/T2). Researchers also employ CDK9 antibodies to explore its therapeutic targeting, particularly in cancer, where CDK9 inhibitors are being investigated to suppress oncogene transcription.

Specificity is a key consideration, as CDK9 shares homology with other CDKs. High-quality antibodies distinguish CDK9 from related kinases (e.g., CDK7) and detect post-translational modifications. Their applications extend to drug development, biomarker studies, and mechanistic research in diseases like leukemia, solid tumors, and viral infections. Recent studies also highlight CDK9’s involvement in epigenetic regulation, expanding the utility of these antibodies in interdisciplinary research.

       
關(guān)鍵字: CDK9抗體;CDK9;CDK9 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠(chǎng),試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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