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ApoB抗體,Mouse Monoclonal ApoB Antibody
  • ApoB抗體,Mouse Monoclonal ApoB Antibody
  • ApoB抗體,Mouse Monoclonal ApoB Antibody
  • ApoB抗體,Mouse Monoclonal ApoB Antibody

ApoB抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ApoB抗體英文名稱:Mouse Monoclonal ApoB Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 406 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: ApoB
2025-05-09 ApoB抗體 Mouse Monoclonal ApoB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 406 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesFLDB; LDLCQ4
Entrez GeneID338
clone6G6
WB Predicted band size516kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ApoB expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Immunofluorescence analysis of HepG2 cells using ApoB mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of serun using ApoB mouse mAb (green) and negative control (purple).    


           

參考文獻

以下是3-4條關(guān)于ApoB抗體的模擬參考文獻示例(僅供格式參考,具體文獻需通過數(shù)據(jù)庫核實):

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1. **文獻名稱**: *Monoclonal Antibody Targeting ApoB-100 Reduces Atherosclerosis in Mice*

**作者**: Smith J, et al.

**摘要**: 研究報道了一種靶向ApoB-100的單克隆抗體,通過抑制氧化低密度脂蛋白(oxLDL)的攝取,顯著減少高膽固醇小鼠模型的動脈粥樣硬化斑塊形成,提示其作為潛在降脂療法的可能性。

2. **文獻名稱**: *Autoantibodies Against ApoB-Containing Lipoproteins and Cardiovascular Risk*

**作者**: López-Mejías R, et al.

**摘要**: 該研究發(fā)現(xiàn),血液中針對ApoB的自身體液抗體(IgG型)水平較低與人類心血管事件風(fēng)險增加相關(guān),提示天然ApoB抗體可能具有抗動脈粥樣硬化的保護作用。

3. **文獻名稱**: *ApoB-Specific Antibody-Drug Conjugate for Targeted Lipid Lowering*

**作者**: Zhang Y, et al.

**摘要**: 開發(fā)了一種新型抗體-藥物偶聯(lián)物(ADC),通過ApoB抗體靶向遞送siRNA至肝臟細胞,特異性沉默ApoB基因表達,顯著降低血清LDL-C水平,為家族性高膽固醇血癥提供治療新策略。

4. **文獻名稱**: *Structural Basis of ApoB Recognition by Neutralizing Antibodies*

**作者**: Binder CJ, et al.

**摘要**: 通過冷凍電鏡解析了人源ApoB抗體與ApoB-100蛋白的結(jié)合表位,揭示了抗體通過阻斷ApoB與LDL受體相互作用來促進脂蛋白清除的分子機制。

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**注**: 以上為示例文獻,實際引用請通過 **PubMed/Google Scholar** 檢索關(guān)鍵詞如 *"ApoB antibody" "atherosclerosis"* 或 *"ApoB immunotherapy"* 獲取真實文獻。

       

背景信息

Apolipoprotein B (ApoB) is a critical structural and functional component of atherogenic lipoproteins, including low-density lipoprotein (LDL) and lipoprotein(a). It plays a central role in lipid metabolism by mediating the binding of these particles to cellular receptors, particularly the LDL receptor (LDLR). ApoB exists in two forms: ApoB-100 (full-length, synthesized in the liver) and ApoB-48 (truncated, produced in the intestine). Antibodies targeting ApoB have garnered significant interest in cardiovascular research due to their potential to modulate lipid metabolism and atherosclerosis.

Naturally occurring autoantibodies against ApoB have been identified in humans, with studies suggesting a possible protective role against cardiovascular disease by promoting the clearance of oxidized LDL or inhibiting plaque inflammation. These endogenous antibodies may influence disease progression, though their clinical significance remains under investigation.

In laboratory settings, monoclonal and polyclonal ApoB antibodies are widely used as research tools to quantify ApoB-containing lipoproteins, study their metabolism, and assess cardiovascular risk. Therapeutic applications are also being explored, including ApoB-targeted vaccines and antibody-based therapies designed to neutralize atherogenic particles or enhance their clearance. Notably, some experimental antibodies aim to block ApoB's interaction with proteoglycans in arterial walls, a key step in plaque formation. However, challenges persist in developing clinically viable ApoB antibodies, balancing efficacy with safety concerns related to potential off-target effects. Current research continues to unravel the complex roles of ApoB immunity in both pathological and protective contexts.

       
關(guān)鍵字: ApoB抗體;ApoB;ApoB Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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