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CD105抗體,Mouse Monoclonal CD105 Antibody
  • CD105抗體,Mouse Monoclonal CD105 Antibody
  • CD105抗體,Mouse Monoclonal CD105 Antibody
  • CD105抗體,Mouse Monoclonal CD105 Antibody

CD105抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CD105抗體英文名稱:Mouse Monoclonal CD105 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 411 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: CD105
2025-05-09 CD105抗體 Mouse Monoclonal CD105 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 411 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesENG; END; ORW; HHT1; ORW1; CD105; FLJ41744
Entrez GeneID2022
clone3A9
WB Predicted band size71kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD105 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Immunofluorescence analysis of HepG2 cells using CD105 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HepG2 cells using CD105 mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于CD105抗體的3篇參考文獻示例(文獻信息為模擬,供參考):

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1. **標題**:*Endoglin (CD105) as a marker of tumor vasculature in colorectal cancer*

**作者**:Dallas NA, et al.

**摘要**:該研究通過免疫組化分析發(fā)現(xiàn),CD105在結(jié)腸癌新生血管內(nèi)皮細胞中特異性高表達,其抗體可有效區(qū)分腫瘤血管與正常血管,提示CD105作為腫瘤血管標志物的潛力,與患者預(yù)后相關(guān)。

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2. **標題**:*Targeting CD105 with monoclonal antibodies in anti-angiogenic therapy of melanoma*

**作者**:Fonsatti E, et al.

**摘要**:研究評估了抗CD105單克隆抗體(如TRC105)在黑色素瘤治療中的作用,顯示其可通過阻斷TGF-β信號通路抑制腫瘤血管生成,并在動物模型中顯著降低腫瘤生長速率。

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3. **標題**:*CD105 antibody-based isolation of mesenchymal stem cells from human bone marrow*

**作者**:Barry FP, et al.

**摘要**:文章提出利用CD105抗體從骨髓中高效分選間充質(zhì)干細胞(MSCs),證實CD105是MSCs的核心表面標記物,為干細胞治療和組織工程提供了可靠的分離方法。

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如需具體文獻,建議通過PubMed或Web of Science檢索關(guān)鍵詞“CD105 antibody”并篩選近年高引論文。

       

背景信息

CD105. also known as endoglin, is a transmembrane glycoprotein that serves as a co-receptor in the transforming growth factor-beta (TGF-β) signaling pathway. It is primarily expressed on proliferating vascular endothelial cells, making it a key marker for studying angiogenesis and vascular remodeling. CD105 plays a critical role in modulating cellular responses to TGF-β1 and TGF-β3. influencing processes such as cell adhesion, migration, and tissue morphogenesis. Its overexpression is associated with pathological angiogenesis in cancers, cardiovascular diseases, and inflammatory conditions.

CD105 antibodies are widely used in research and diagnostics to identify and isolate endothelial cells, particularly in tumor vasculature, where CD105 is upregulated. These antibodies enable the detection of microvessel density in tumor tissues, a prognostic indicator in oncology. Additionally, CD105-targeted imaging and therapeutic agents are under investigation for cancer treatment due to their potential to selectively target tumor blood vessels.

In immunology, CD105 antibodies aid in characterizing mesenchymal stromal cells (MSCs), as CD105 is a defining surface marker. Recent advances include the development of anti-CD105 monoclonal antibodies for experimental therapies, such as antibody-drug conjugates (ADCs) and immunotherapies aimed at inhibiting aberrant angiogenesis. Despite its prominence, CD105's dual role in pro- and anti-angiogenic signaling underscores the complexity of its biological functions, necessitating further research to optimize clinical applications.

       
關(guān)鍵字: CD105抗體;CD105;CD105 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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