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AIF抗體,Mouse Monoclonal AIF Antibody
  • AIF抗體,Mouse Monoclonal AIF Antibody
  • AIF抗體,Mouse Monoclonal AIF Antibody
  • AIF抗體,Mouse Monoclonal AIF Antibody

AIF抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:AIF抗體英文名稱:Mouse Monoclonal AIF Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 427 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: AIF
2025-05-09 AIF抗體 Mouse Monoclonal AIF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 427 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat,,Monkey
IF咨詢技術(shù) Human,Mouse,Rat,,Monkey
IHC1/200 - 1/1000 Human,Mouse,Rat,,Monkey
ICC1/200 - 1/1000 Human,Mouse,Rat,,Monkey
FCM1/200 - 1/400 Human,Mouse,Rat,,Monkey
Elisa1/10000 Human,Mouse,Rat,,Monkey
   

產(chǎn)品詳情

AliasesAIFM1; AIF; PDCD8; COXPD6; MGC111425
Entrez GeneID9131
clone4E7
WB Predicted band size67kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,,Monkey
ImmunogenPurified recombinant fragment of human AIF expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using AIF mouse mAb against NIH/3T3 (1), Jurkat (2), Hela (3), HepG2 (4), MOLT4 (5), C6 (6), RAJI (7), Cos7 (8) and PC-12 (9) cell lysate.    


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       Western blot analysis using AIF mouse mAb against CHO3D10(1),COS7(2),F9(3),L1210(4),C6(5),C2C12(6),NIH/3T3(7),Raw264.7(8),PC-12(9) cell lysate.    


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       Immunofluorescence analysis of NIH/3T3 cells using AIF mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunofluorescence analysis of RSC-96 cells using AIF mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Immunofluorescence analysis of NIH3T3 cells using AIF mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Flow cytometric analysis of HepG2 cells using AIF mouse mAb (blue) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using AIF mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using AIF mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using AIF mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using AIF mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse liver(A) Mouse kidney(B) using AIF mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat liver(A) Rat kidney(B) using AIF mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于AIF抗體的3篇參考文獻及其摘要概括:

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1. **文獻名稱**: *Molecular characterization of mitochondrial apoptosis-inducing factor*

**作者**: Susin, S. A., et al.

**摘要**: 該研究首次克隆并鑒定了AIF蛋白,證明其從線粒體釋放至細胞核可觸發(fā)凋亡,實驗中利用AIF抗體驗證其亞細胞定位及功能,為后續(xù)凋亡機制研究奠定基礎(chǔ)。

2. **文獻名稱**: *Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death*

**作者**: Joza, N., et al.

**摘要**: 通過構(gòu)建AIF缺陷小鼠模型,結(jié)合AIF抗體檢測,發(fā)現(xiàn)AIF缺失導致胚胎致死及神經(jīng)細胞凋亡異常,證實AIF在發(fā)育和細胞程序性死亡中的關(guān)鍵作用。

3. **文獻名稱**: *Apoptosis-inducing factor (AIF): a key regulator of apoptotic and necrotic neural cell death*

**作者**: Cheung, E. C., et al.

**摘要**: 研究AIF在腦缺血中的角色,使用AIF抗體揭示其在缺氧時從線粒體轉(zhuǎn)位至細胞核的過程,并關(guān)聯(lián)其與壞死性細胞死亡的調(diào)控機制。

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這些文獻涵蓋了AIF抗體的基礎(chǔ)研究、功能驗證及疾病模型應(yīng)用,適用于凋亡機制和實驗方法參考。

       

背景信息

**Background of AIF Antibody**

The Apoptosis-Inducing Factor (AIF) is a mitochondrial flavoprotein with dual roles in cellular homeostasis and apoptosis. Initially identified for its involvement in caspase-independent programmed cell death, AIF translocates from mitochondria to the nucleus under apoptotic stimuli, triggering chromatin condensation and DNA fragmentation. Beyond apoptosis, AIF is critical for maintaining mitochondrial structure, bioenergetics, and redox balance, supported by its role in regulating respiratory chain complexes.

AIF antibodies are essential tools in studying these processes. They enable detection of AIF’s subcellular localization (e.g., via immunofluorescence) and expression levels (e.g., via Western blot), helping to dissect its pro-apoptotic versus pro-survival functions. Research using AIF antibodies has revealed its involvement in neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s), ischemic injuries, and cancer, where AIF dysregulation correlates with pathological outcomes.

Structurally, AIF antibodies often target conserved epitopes, such as the N-terminal mitochondrial localization signal or C-terminal DNA-binding domain. Some antibodies distinguish between full-length AIF (~67 kDa) and its truncated forms, which arise during apoptosis. The development of selective AIF antibodies has advanced therapeutic exploration, including strategies to inhibit AIF-mediated apoptosis in neurodegeneration or enhance its pro-death role in cancer. Overall, AIF antibodies remain pivotal in unraveling the multifaceted biology of AIF and its translational potential.

       
關(guān)鍵字: AIF抗體;AIF;AIF Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (3年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會員
  • 公司成立:3年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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