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C-CBL抗體,Mouse Monoclonal C-CBL Antibody
  • C-CBL抗體,Mouse Monoclonal C-CBL Antibody
  • C-CBL抗體,Mouse Monoclonal C-CBL Antibody
  • C-CBL抗體,Mouse Monoclonal C-CBL Antibody

C-CBL抗體 新品

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):C-CBL抗體英文名稱(chēng):Mouse Monoclonal C-CBL Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 431 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): C-CBL
2025-05-09 C-CBL抗體 Mouse Monoclonal C-CBL Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 431 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat,Rabbit
IF咨詢(xún)技術(shù) Human,Mouse,Rat,Rabbit
IHC1/100 - 1/500 Human,Mouse,Rat,Rabbit
ICC1/50 - 1/500 Human,Mouse,Rat,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rat,Rabbit
Elisa1/10000 Human,Mouse,Rat,Rabbit
   

產(chǎn)品詳情

AliasesCBL; CBL2; NSLL; C-CBL; RNF55
Entrez GeneID867
clone3B12
WB Predicted band size120kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Monkey,Rabbit
ImmunogenPurified recombinant fragment of human C-CBL expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using C-CBL mouse mAb against RAJI (1), RAW264.7 (2), K562 (3), SKBR-3 (4), 3T3-L1 (5), THP-1 (6) and PC-12 (7) cell lysate.    


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       Western blot analysis using C-CBL mouse mAb against PC-12(1)Raw264.7(2)NIH/3T3(3)NRK(4)C2C12(5)C6(6)F9(7)COS-7(8) cell lysate.    


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       Immunofluorescence analysis of Hela cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunofluorescence analysis of COS7 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Immunofluorescence analysis of PC-12 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Immunofluorescence analysis of NIH/3T3 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Flow cytometric analysis of MCF-7 cells using C-CBL mouse mAb (blue) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C-CBL mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using C-CBL mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse kidney using C-CBL mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using C-CBL mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit kidney using C-CBL mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于C-CBL抗體的假設(shè)參考文獻(xiàn)示例(非真實(shí)文獻(xiàn),僅供格式參考):

1. **文獻(xiàn)名稱(chēng)**:C-CBL regulates T-cell receptor signaling through ubiquitination of key signaling molecules

**作者**:Smith A, et al.

**摘要**:研究利用C-CBL特異性抗體進(jìn)行免疫共沉淀實(shí)驗(yàn),揭示C-CBL通過(guò)泛素化修飾負(fù)調(diào)控T細(xì)胞受體下游信號(hào)分子(如ZAP-70),影響T細(xì)胞活化。

2. **文獻(xiàn)名稱(chēng)**:C-CBL expression and function in acute myeloid leukemia

**作者**:Zhang L, et al.

**摘要**:通過(guò)Western blot和免疫組化(使用C-CBL抗體),發(fā)現(xiàn)C-CBL在A(yíng)ML患者中表達(dá)降低,其缺失導(dǎo)致異常增殖信號(hào)通路激活,提示其作為腫瘤抑制因子的潛在作用。

3. **文獻(xiàn)名稱(chēng)**:Structural insights into C-CBL E3 ligase activity by antibody-mediated epitope mapping

**作者**:Johnson R, et al.

**摘要**:利用C-CBL抗體識(shí)別其泛素連接酶結(jié)構(gòu)域,結(jié)合X射線(xiàn)晶體學(xué),闡明C-CBL與底物結(jié)合的分子機(jī)制,為靶向藥物設(shè)計(jì)提供依據(jù)。

4. **文獻(xiàn)名稱(chēng)**:C-CBL modulates EGFR endocytosis via tyrosine phosphorylation in lung cancer

**作者**:Tanaka H, et al.

**摘要**:通過(guò)C-CBL抗體阻斷實(shí)驗(yàn),證實(shí)C-CBL通過(guò)促進(jìn)EGFR泛素化驅(qū)動(dòng)其內(nèi)吞降解,抑制肺癌細(xì)胞增殖,提示靶向C-CBL-EGFR軸的治療潛力。

(注:以上內(nèi)容為模擬示例,實(shí)際文獻(xiàn)需通過(guò)學(xué)術(shù)數(shù)據(jù)庫(kù)檢索。)

       

背景信息

C-CBL (Casitas B-lineage lymphoma) is a multifunctional adaptor protein and E3 ubiquitin ligase involved in regulating intracellular signaling pathways, particularly those linked to tyrosine kinase receptors. It plays a critical role in ubiquitination-mediated degradation of activated receptors and signaling molecules, thereby modulating cell proliferation, differentiation, and apoptosis. Dysregulation of C-CBL is implicated in various cancers and immune disorders due to mutations or altered expression levels that disrupt its tumor-suppressive or oncogenic functions, depending on cellular context.

C-CBL antibodies are essential tools for studying its expression, post-translational modifications, and interactions in both physiological and pathological settings. These antibodies enable detection of C-CBL in techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding research into its role in leukemia, solid tumors, and autoimmune diseases. Some studies highlight its dual nature—acting as a tumor suppressor by downregulating oncogenic signaling (e.g., in EGFR pathways) or promoting malignancy when mutated. Additionally, C-CBL antibodies help explore its involvement in immune cell regulation, such as T-cell receptor signaling. Research using these antibodies contributes to understanding disease mechanisms and potential therapeutic targeting of C-CBL-associated pathways.

       
關(guān)鍵字: C-CBL抗體;C-CBL;C-CBL Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏(yíng)得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠(chǎng),試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
普通會(huì)員
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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